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Marks Breyanzi’s fourth indication in Europe, adding to existing approvals for several aggressive B-cell lymphomas.
November 25, 2025
By: Charlie Sternberg
Associate Editor
The European Commission (EC) has granted approval to Bristol Myers Squibb’s Breyanzi (lisocabtagene maraleucel; liso-cel), a CD19-directed chimeric antigen receptor (CAR) T cell therapy, for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy including a Bruton’s tyrosine kinase (BTK) inhibitor. “This approval for Breyanzi in relapsed or refractory mantle cell lymphoma marks another important step as we continue t...
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